VTS Fusion Xpress™


Fusion Xpress™ injectable bone putty is a combination of demineralized bone (DBM) with mineralized cancellous chips and biphasic calcium phosphate (BCP) in a resorbable carrier. The BCP consists of beta-tricalcium phosphate (β-TCP) and hydroxyapatite (HA), both found naturally in real bone.

How It Works

The KEY to success with engineered combination products is the balance of intrinsic growth factors (e.g., BMP’s) in DBM and phased synthetic graft resorption. This powerful combination creates an enhanced environment that supports osseous regeneration throughout the stages of healing, resulting in bony FUSION™. Combining osteoconductive biphasic synthetics with an osteoinductive agent such as DBM is a most promising combination for achieving reliably successful fusion without the use of autograft.3



• Void filling / Extraction sites
• Periodontal pockets
• Bone loss
• Mandibular fracture repair
• Cysts / Other osseous defects
• Guided Bone Regeneration


• Angular limb deformities
• Void filling / Osteotomy sites
• Comminuted fractures, non or delayed unions
• Arthrodesis
• Anywhere autograft would be used

Features & Benefits

• Excellent Handling Characteristics: Injectable directly out of the syringe into the site! No glove handling required. Resists vigorous irrigation and stays in the site.
• Osteoinductive: It is well documented that DBM contains a full compliment of naturally present BMPs1. These BMPs facilitate the osteoinductivity needed for optimal bone regeneration.
• Osteoconductive: The calcium phosphate minerals consist of beta-tricalcium phosphate (β-TCP) and hydroxyapatite (HA), both found in real bone. The combination of these minerals and real cancellous bone provide a natural osteoconductive scaffold to support in-growth of bone-forming cells and release minerals locally for use in bone mineralization.

Available Product Types

More sizes available through VTS

About VTS

Veterinary Transplant Services, Inc. (VTS) is the world’s first animal tissue bank. VTS provides veterinarians with animal bone and soft tissue allografts for animal use. Using professionally-procured bone allograft saves them from having to procure the patient’s own bone when bone material is needed. This decreases their OR time & cost and spares the patient a second operative site.

Orthopedic surgeons in human medicine have been confidently using bone allografts for decades. As a veterinary version of a human tissue bank, VTS brings this significant medical advancement to veterinarians and are proud of having been doing so successfully since 1996.

Besides the most commonly used Osteoallograft® Orthomix®, cancellous blocks, bone sections, and whole bones are also available for spinal fusions, severe fractures, and limb sparing procedures.

Clinical References


  1. Reddi AH. Initiation of fracture repair by bone morphogenetic proteins. Clin Orthop Relat Res. (355S) Suppl: S66-72, 1998
  2. Spivak JM, Hasharoni A. Use of hydroxyapatite in spine surgery. Eur Spine J. 10: S197-S204, 2001
  3. Daculsi et al., Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization. J Bio Mat Res 23:883-94,1989
  4. Spivak JM, Hasharoni A. Use of hydroxyapatite in spine surgery. Eur Spine J. 10: S197-S204, 2001
  5. Farina, N. M., F. M. Guzon, M. L. Pena, and A. G. Cantalapiedra. “In Vivo Behaviour of Two Different Biphasic Ceramic Implanted in Mandibular Bone of Dogs.” J Mater Sci Mater Med. 19(4):1565-1573, 2008.
  6. Di Stefano, D. A., L. Artese, G. Iezzi, A. Piattelli, S. Pagnutti, M. Piccirilli, and V. Perrotti. “Alveolar Ridge Regeneration with Equine Spongy Bone: A Clinical, Histological, and Immunohistochemical Case Series.” Clin Implant Dent Relat Res. 11(2): 90-100, 2009.
  7. Barbieri, D., H. Yuan, F. de Groot, W. R. Walsh, and J. D. de Bruijn. “Influence of Different Polymeric Gels on the Ectopic Bone Forming Ability of an Osteoinductive Biphasic Calcium Phosphate Ceramic.” Acta Biomater. 7(5):2007-2014, 2011.
  8. Bongio, M., van den Beucken, J. J., Leeuwenburgh, C. G., Jansen, J. A. “Development of Bone Substitute Materials: From ‘Biocompatible’ to ‘Instructive’.” J Mater Chem. 20:8747-8759, 2010.
  9. Spivak, J. M., and A. Hasharoni. “Use of Hydroxyapatite in Spine Surgery.” Eur Spine J. 10 Suppl 2: S197-204, 2001.
  10. Hashimoto-Uoshima, M., I. Ishikawa, A. Kinoshita, H. T. Weng, and S. Oda. “Clinical and Histologic Observation of Replacement of Biphasic Calcium Phosphate by Bone Tissue in Monkeys.” Int J Periodontics Restorative Dent. 15(2): 205-13, 1995.
  11. Reynolds, M. A., M. E. Aichelmann-Reidy, G. L. Branch-Mays, and J. C. Gunsolley. “The Efficacy of Bone Replacement Grafts in the Treatment of Periodontal Osseous Defects. A Systematic Review.” Ann Periodontol. 8(1): 227-265, 2003. (Humans; retrospective meta-analysis)
  12. Stein, J. M., S. Fickl, S. S. Yekta, U. Hoischen, C. Ocklenburg, and R. Smeets. “Clinical Evaluation of a Biphasic Calcium Composite Grafting Material in the Treatment of Human Periodontal Intrabony Defects: A 12-Month Randomized Controlled Clinical Trial.” J Periodontol. 80(11): 1774-1782, 2009. (Human; controlled prospective clinical trial)
  13. Friedmann, A., M. Dard, B. M. Kleber, J. P. Bernimoulin, and D. D. Bosshardt. “Ridge Augmentation and Maxillary Sinus Grafting with a Biphasic Calcium Phosphate: Histologic and Histomorphometric Observations.” Clin Oral Implants Res. 20(7): 708-14, 2009. (Humans)
  14. Arts, J. J., L. H. Walschot, N. Verdonschot, B. W. Schreurs, and P. Buma. “Biological Activity of Tri-Calcium phosphate/Hydroxyl-Apatite Granules Mixed with Impacted Morsellized Bone Graft. A Study in Rabbits.” J Biomed Mater Res B Appl Biomater. 81(2): 476-485, 2007.
  15. Daculsi, G., N. Passuti, S. Martin, C. Deudon, R. Z. Legeros, and S. Raher. “Macroporous Calcium Phosphate Ceramic for Long Bone Surgery in Humans and Dogs. Clinical and Histological Study.” J Biomed Mater Res. 24(3): 379-96, 1990.
  16. Gaasbeek, R. D., H. G. Toonen, R. J. van Heerwaarden, and P. Buma. “Mechanism of Bone Incorporation of Beta-TCP Bone Substitute in Open Wedge Tibial Osteotomy in Patients.” Biomaterials. 26(33): 6713-6719, 2005.
  17. Kaushick, B. T., N. D. Jayakumar, O. Padmalatha, and S. Varghese. “Treatment of Human Periodontal Infrabony Defects with Hydroxyapatite + Beta Tricalcium Phosphate Bone Graft Alone and in Combination with Platelet Rich Plasma: A Randomized Clinical Trial.” Indian J Dent Res. 22(4): 505-510, 2011.
  18. Lee, M. J., B. O. Kim, and S. J. Yu. “Clinical Evaluation of a Biphasic Calcium Phosphate Grafting Material in the Treatment of Human Periodontal Intrabony Defects.” J Periodontal Implant Sci. 42(4): 127-135, 2012.
  19. Pratt, J. N., D. J. Griffon, D. G. Dunlop, N. Smith, and C. R. Howie. “Impaction Grafting with Morsellised Allograft and Tricalcium Phosphate-Hydroxyapatite: Incorporation within Ovine Metaphyseal Bone Defects.” Biomaterials. 23(16): 3309-3317, 2002.
  20. Ridgway, H. K., J. T. Mellonig, and D. L. Cochran. “Human Histologic and Clinical Evaluation of Recombinant Human Platelet-Derived Growth Factor and Beta-Tricalcium Phosphate for the Treatment of Periodontal Intraosseous Defects.” Int J Periodontics Restorative Dent. 28(2):171-179, 2008.